The Chifley Houston, Tapestry Collection by HiltonvsDoubleTree by Hilton Houston Medical Center Hotel & Suites
Both properties are rated very highly by professional reviewers. Overall, Sheraton Suites Houston Near The Galleria ranks slightly higher than Wyndham Houston - Medical Center Hotel and Suites. Sheraton Suites Houston Near The Galleria comes in at 78 with accolades from 4 reviewers such as Frommer's, Gayot and Oyster.
The Chifley Houston, Tapestry Collection by Hilton
 Frommer's
 Oyster
 Zagat
 Gayot
2400 West Loop South, Houston, TX 77027
From $78/night
- Pet Friendly
 - Bar/Lounge
 - Hot Tub
 - Free Internet
 - Room Service
 - Shuttle Bus
 
 "The rooms at this all-suite hotel are attractive, with more character than most hotel rooms in the Galleria area." Full review
Upper-middle-range
 "Sheraton Suites' reputation as a business-friendly chain lives up to its name in this professional, unpretentious hotel near the Houston Galleria." Full review
4.3
 "This all-suite venue, situated in a "prime" location two blocks from the Galleria shopping mall, offers "nice, spacious" accommodations and "personable" employees." 
 "Located around the corner from the Galleria (shoppers love staying here), this 281-room hotel is also convenient for business people." 
DoubleTree by Hilton Houston Medical Center Hotel & Suites
 Frommer's
 Gayot
 Oyster
6800 Main Street, Houston, TX 77030
From $69/night
- Bar/Lounge
 - Free Internet
 - Shuttle Bus
 - Laundry Service
 - Laundy Room
 - Restaurant
 
 "This hotel has a good location across from the Medical Center, at the intersection with Holcombe Boulevard." Full review
 "Formerly a Holiday Inn, this twelve-story hotel is south of downtown Houston and adjacent to the world-renowned Texas Medical Center." 
Upper-middle-range
 "The upper-middle-range Wyndham Houston – Medical Center Hotel and Suites offers comfortable accommodations at affordable rates, within walking distance of Texas Medical Center." Full review