Hotel New Otani OsakavsHotel Mystays Sakaisuji-Honmachi
Both properties are endorsed by those who travel for a living. Overall, Hotel New Otani Osaka is preferred by most writers compared to Hotel Mystays Sakaisuji-Honmachi. Hotel New Otani Osaka ranks #8 in Osaka with endorsements from 4 reviews such as Fodor's, Michelin Guide and Oyster.
Hotel New Otani Osaka
 Lonely Planet
 Fodor's
 Oyster
 Michelin Guide
1-4-1 Chuo-ku Shiromi, Osaka, Osaka Prefecture 540-8578
From $131/night
- Bar/Lounge
 - Hot Tub
 - Free Internet
 - Room Service
 - Shuttle Bus
 - Laundry Service
 
 "The sprawling hotel has one of the best hotel locations in all of Osaka." Full review
 "Indoor and outdoor pools, a rooftop garden, tennis courts, and a sparkling marble atrium make this hotel a popular choice for both Japanese and Western travelers." Full review
Upscale
 "The four-pearl Hotel New Otani Osaka is a massive multi-story hotel with 525 guest rooms located in a business district, a short walk from Osaka Castle (which is visible from some rooms)." Full review
 "The hotel is a 30-minute taxi ride from Osaka International Airport and Shin-Osaka Station, and there is a shuttle bus from Kansai International Airport." Full review
 i 
Try to get a room equipped with ‘bedroom environment systems’ for business travellers as they have massage chairs.
Hotel Mystays Sakaisuji-Honmachi
 Oyster
1-4-8 Awajimachi, Chuo-ku, (Former Mystays Inn Sakaisuji-Honmach), Osaka, Osaka Prefecture 541-0047
From $30/night
- Hot Tub
 - Free Internet
 - Laundry Service
 - Laundy Room
 - Restaurant
 - Smoking Rooms
 
Mid-Range
 "There are 189 guest rooms at this three-pearl property set in a quiet, residential area of central Osaka." Full review