A century-old Uptown institution in a rustic, no-frills shack, beloved for fried seafood po'boys—especially shrimp and oyster—on crusty French bread. Divey charm, unbeatable local reputation.
"A dilapidated white shack by the river serving Dixie beer (brewed in Wisconsin!), staffed by folks who've worked here for decades and dressing one of the most legendary po' boys... in the city." Full review
Travel + Leisure
"Don’t let the modest, rustic appearance and off-the-beaten-path location of Domilise’s Po-Boy & Bar on Annuciation Street fool you. The food here is well-worth a sidetrack." Full review
Zagat
4.3
"A "New Orleans institution", this Uptown po' boy "joint" has been serving "crusty" French loaves "overstuffed" with "fat", "crispy" oysters." Full review
Gayot
12.0
"Domilise's is a local institution, but don't expect anything fancy or any pampering --- it's all about the food." Full review
DK Eyewitness
"Most Uptown locals swear that these are the best po’boys in town, and it is a good argument considering the fresh local seafood is fried to perfection."
Not For Tourists
"Old dive with to-die for (but mostly unaffordable) po boys."
Where
"Located down a side street in a rambling old Uptown house, Domilise's is the quintessential po’ boy joint." Full review
Tasting Table
"If you're going to get a seafood po-boy in New Orleans, never settle." Full review
Frommer's
"At the century-old, cluttered, lowdown poor-boy shop tucked away Uptown, your hands-down order is the wet-dry, battered-and-fried-to-order shrimp, piled onto puffy poor-boy loaves " Full review
Fodor's
"This po'boy institution has been around in one form or another for more than a century, but the way the corner restaurant fills up each day for lunch is proof neither New Orleanians or..." Full review
Experts' Choice Award 
Lonely Planet
Travel + Leisure
Zagat
Gayot
DK Eyewitness
Not For Tourists
Where
Tasting Table
Frommer's
Fodor's
